The Medical Research Council is a government-funded organisation whose mission is to promote improvements in human health through research. The spectrum of research supported varies from the purely clinical through to fundamental research in the biomedical sciences. The MRC supports research through a variety of mechanisms, including funding of grant applications made by academics in universities, and the establishment of research Institutes, Centres and Units with remits in particular disciplines. The MRC Virology Unit in Glasgow has been at the international forefront of virology research, particularly that involving HSV-1, for almost 40 years. The Unit is equipped to a high standard and has access to all the expertise and facilities required for the proposed work programme.

Roger Everett

Roger Everett is a principal scientist and group leader in the Medical Research Council Virology Unit, heading a group investigating herpes simplex virus gene expression and latency. Dr Everett has established an international reputation as a leading expert in the regulation of HSV gene expression, particularly that involving ICP0. During this time he has authored almost 100 publications on topics related to this proposal. Many of the most important and influential discoveries in this field in recent years have come from his laboratory. He has an unrivalled panel of virus mutants and other reagents that will be essential for WP6. Along with the current members of his research team, Dr Everett has personal, successful experience of the methodologies that will be used in WP6, including virus construction, protein isolation and proteomic analysis, the use of siRNA and shRNA reagents, and phenotypic analysis of cell lines and virus mutants.

Relevant publications/patents

• Boutell, C., Sadis, S. and Everett, R.D.: HSV-1 Immediate-Early protein ICP0 and its isolated RING finger domain act as ubiquitin E3 ligases in vitro. Journal of Virology, 76, 841-850. (2002)
• Boutell, C., Orr, A. and Everett, R.D.: PML residue lysine 160 is required for the degradation of PML induced by HSV-1 regulatory protein ICP0. Journal of Virology, 77, 8686-8694. (2003)
• Everett, R.D., Boutell, C. and Orr, A.: The phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0. Journal of Virology, 78, 1763-1774. (2004)
• Canning, M., Boutell, C., Parkinson, J. and Everett, R.D.: A RING finger ubiquitin ligase is protected from auto-catalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7. Journal of Biological Chemistry, 279, 38160-38168. (2004)
• Everett, R.D and Murray, J.: ND10 components relocate to sites associated with HSV-1 nucleoprotein complexes during virus infection. Journal of Virology, 79, 5078-5089. (2005)
  

Contact:

Dr. Roger Everett
Medical Research Council
Tel.: +44 141 330 3923
Fax: +44 141 337 2236
E-Mail: r.everett@mrcvu.gla.ac.uk
Website: www.mrc.co.uk